British

Microcirculation

Society

Honorary Secretary:

Dr David Bates

Microvascular Research Laboratories

Department of Physiology

Preclinical Veterinary School

University of Bristol

Southwell Street, Bristol, BS2 8EJ

Tel 0117 928 9818

Fax 0117 928 8151

Email: Dave.Bates@bris.ac.uk

 

NEWSLETTER – SUMMER 2003

 

Dear All,

 

Now that I have collected my wits together and recovered from hosting the 2003 Spring Meeting of the Society, I though it about time to update you all with recent developments in the world of Microcirculation in the UK and beyond.

 

2003 SPRING MEETING

 

I hope those of you that attended this year’s Spring Meeting in Bristol in April enjoyed yourselves, and I would like to thank those that came for making it a successful event. The meeting was exceptionally well attended by 78 members, 51 guests and 21 trade exhibitors, making it the largest scientific meeting in the society’s history. In addition to the symposium on recent advances in lymphatic research, there were 28 oral communications and 59 poster presentations over the two days, organised into 13 thematic sessions. The meeting had presentations on regulation of microvascular flow, organ specific microcirculation, vascular cell biology, lymphatics, interstitium and the extracellular matrix, vascular permeability, angiogenesis, microangiopathy, tumour microcirculation, diabetes, skin blood flow, retinopathy, and inflammation. The society made two awards, The Terence Ryan Award to Sarah Hughes from Queen’s University, Belfast for her abstract entitled “The role of advanced glycation end-products (AGEs) in pericyte dysfunction during diabetic retinopathy” and the Moor Instruments Award to Robin Hamilton from Nottingham University for his abstract entitled “Characterisation of an in vitro model for studies into age related macula degeneration”. The Society also helped pay for the costs of six other student members to attend the meeting through its Student Assistance Scheme.

           

The Society Dinner was held in the Bristol City Museum adjacent to the University, and was preceded by a reception in the museum under a replica of a Bristol Boxkite aircraft, a star of the 1963 film “Those Magnificent Men in their Flying Machines,” that were built in Bristol from 1910 to 1914. The dinner was followed by retirement to a local hostelry where discussions about microcirculation and associated issues continued until well into the following morning. I would like to take this opportunity to thank the people that helped me organise the meeting, in particular all the students, postdocs and technicians in the Microvascular Research Laboratories here in Bristol for their invaluable support in organising the meeting, which we took to be a great success. I wish Nicky all the best in organising next year’s meeting in Sheffield.

 

 

Forthcoming British Microcirculation Society Meeting

41st Annual Spring Meeting, University of Sheffield, 5-6 April 2004

           

The annual spring meeting and Annual General Meeting of the British Microcirculation Society will take place on the 5th and 6th of April 2004, hosted by the University of Sheffield. The meeting will be held in Tapton Masonic Hall, which has excellent facilities for presentations, with the posters and trade exhibition to be situated in adjoining accommodation where refreshments will be served. Next year the meeting will be generously supported by The Wellcome Trust and Cancer Research UK, with support also requested from the Physiological Society. There will be an informal meal on Sunday evening for those delegates arriving in Sheffield early, but the scheduled 11am start should allow travel from most parts of the country.

 

The scientific symposium “Tumour microcirculation: development and therapeutic targeting” will include presentations from Hellmut Augustin (Germany), Roy Bicknell (UK), Ian Hart (UK), Shay Shoker (US), Claire Lewis (UK) and Gill Tozer (UK). In addition we will endeavour to follow the successful format employed in Bristol with abstracts allocated into themes, both oral and posters, but this will depend on the spectrum of research submitted. We hope to have oral or poster sessions on the following topics, although this may change depending on the abstracts submitted. If you want to ensure a theme is included, submit abstracts, and persuade your colleagues to do likewise.

 

Adaptation to physical forces                                      Lymphatics and oedema

Angiogenesis                                                               Microvascular exchange

Diabetes and hypertension                                          Organ specific microcirculation

Endothelial cell biology                                              Pulmonary endothelium

Hypoxia and hyperoxia in the microcirculation           Regulation of vascular tone

Inflammation and leukocyte interactions                     Tumour microcirculation

Interstitium and the extracellular matrix                      Vascular development

Vascular permeability

 

There will be one oral presentation prize session dedicated to abstracts selected by the Society’s awards committee on the basis of the quality and impact of their research. Two awards will be presented - the Terence Ryan Young Investigator Award and the Moor Instruments Travel Award (see application details below).

 

Full details of the meeting, and the award schemes, including downloadable forms, will shortly be available at this web site. Accommodation will be available at Tapton Hall of Residence, £40 single en suite; this University student accommodation is approximately 15 minutes walk from the venue. There are also moderately priced hotels within a short walk from the conference venue. Sheffield is situated close to the Peak District and the Society's Dinner will be held at Hassop Hall in Derbyshire. We have applied for a late licence at Tapton to continue the tradition of lively discussion until late in the evening. We look forward to welcoming you all to Sheffield.

 

Future Meetings

2005 BMS Meeting, Durham, New Hampshire, September 2005.

The 2005 Annual Meeting of the Society will be a departure from the normal format of the meeting.

This is in part due to the need to avoid conflicts with the International Union of Physiological Sciences meeting in April 2005 in San Diego. The Committee has proposed to hold a joint meeting in September 2005 with the American “Microcirculatory Society” at the University of New Hampshire in Durham, NH. The meeting will follow the same format as the normal BMS meetings (including talks based on abstract submission and one symposium on a selected topic) but will be a three day meeting, starting Saturday evening, and finishing on Tuesday afternoon. The symposium will be on “Role of Reactive Oxygen Radicals in Vascular Cell Signaling in Health and Disease”. The proposed dates are the 10th-13th September 2005. Durham is approximately 1.5 hours north of Boston International Airport. The society will be providing a great deal of support for graduate students and postdocs to attend the meeting, to try and reduce the cost for those attending to approximately £250 including flights, accommodation, meals and registration. Registration and accommodation for senior investigators is likely to be around £300 not including flights. The society aims to help up to 50 postdocs and students with their expenses for the meeting.

 

2006 BMS Meeting, University of Dundee

Dr Faisal Khan is organising the 2006 BMS meeting at the University of Dundee. Further information will be forthcoming in subsequent Newsletters.

 

Forthcoming BMS Sponsored Meetings

British Association Meeting Exeter 6-10 September 2004

“Small is Beautiful” (and clinically important). We are delighted to announce that the BMS has been selected to contribute to the BA Festival of Science to be hosted at the University of Exeter 6-10 September 2004. The session will explore the importance of the microcirculation in health and disease and the exciting emerging technologies applied to human studies. The preliminary programme includes the following contributions:

 

The vital role of blood vessels smaller than a human hair. Professor Angela Shore

Sampling some tissues, how does it help us understand how small blood vessels work? Dr Geraldine Clough Oedema, roles of the microcirculation in the formation of this watery environment. Professor Peter Mortimer

Cardiovascular Disease-is the problem just the big vessels? Dr Faisal Khan

Emerging Technologies-Can we now dig even deeper? Dr Steve Matcher

 

The session will be accompanied by a hands on exploration of blood flow in the skin using up to date technologies based on microscopy, spectroscopy, and laser Doppler.

 

23rd European Conference on Microcirculation

The 23rd European Conference on Microcirculation will be held in Lisbon, Portugal. September 8-10, 2004. The British Microcirculation Society will be sponsoring a symposium at the European Society meeting entitled “Microcirculation in ischaemia-reperfusion injury and preconditioning”. Speakers will include Christopher Torrens, University of Southampton, UK, (Epigenetic Programming of Endothelial Function and the Metabolic Syndrome), Mikael Norman, Karolinska Institute, Stockholm, Sweden (Clinical Implications of Endothelial Dysfunction in IUGR offspring), and Maria do Carmo Pinho Franco, University of Sao Paulo, Brazil (Programming of Endothelial Biochemistry).

 

The Microcirculation Conference Grant

T he aim of the MCG this year is to provide financial assistance for up to two eligible student members of the British Microcirculation Society to attend the European Conference on Microcirculation in Lisbon. Students and post doctoral members of the Society in the initial few years of their first position after obtaining their PhD, whose Supervisor is a full member of the BMS are eligible.

 

The Laboratory Visit Grant

The purpose of this scheme is to assist an eligible student or junior postdoctoral member of the British

Microcirculation Society, to visit a laboratory in this country or abroad for the purpose of learning new techniques or other worthwhile scientific purposes related to microvascular research.

 

NEXT DEADLINE FOR BOTH GRANTS IS 31ST JANUARY 2004

Details of how to apply for these awards are on the BMS website.

 

Committee

Membership of the current committee is given below and we would welcome comments about the working of the Society at any time. At the last AGM, we were pleased to welcome Gillian Tozer, Malcolm Reed and Faisal Khan to the committee for the next four years after a very closely fought election. I would like to thank Giovanni Mann, Stuart Egginton and Nicola Brown for their support and help on the committee over the last four years. Furthermore the committee have indentured a new post – communications officer – filled by Dr Richard Siow from King’s College London. The roles of this post over the next year will be to maintain and further develop the British Microcirculation Society Website – www.microcirculation.org.uk. This website will be undergoing some fairly major transformation in the next twelve months with a number of significant new features added, for the benefit of our membership.

 

Nominations for Treasurer

Our Treasurer, Dr David Harrison, will be stepping down this year after seven years in office. The work he has done has transformed the society in that we now have almost 100% of our members paid up on time, due to the completion of the direct debit system that was initiated by previous treasurers.

We are therefore calling for nominations for this post before the next Annual general meeting. If you would like to volunteer, then please write to me at the address above. The Deadline for nominations will be in February next year, and further details will be sent out with the Winter Newsletter.

 

Current BMS Committee

 

Position

President

Honorary Secretary

Honorary Treasurer

Proceedings Editor

Committee

Committee                              

Committee

Committee                  

Committee

Communications Officer

Name

Professor Jeremy Pearson

Dr David Bates

Dr David Harrison

Dr Margaret Brown

Dr Ariane Herrick

Dr Peter Coleman

Dr Faisal Khan

Professor Malcolm Reed

Dr Gillian Tozer

Dr Richard Siow

Holds office until

2005

2008

2004

2006

2006

2006

2007

2007

2007

N/A Co-opted by committee

 

European Society for Microcirculation (ESM)

At the Annual General Meeting the following motion was voted on and accepted.

British Microcirculation Society Membership can confer membership of the European Microcirculation Society. The subsequent motion, to change the constitution to allow the BMS to include membership of the European Society in its membership fee, did not reach the two thirds majority required to pass, although a clear majority was in favour.

The president is still negotiating on behalf of the society for further benefits to the membership, including increased representation on the ESM committees, promotion of the BMS annual meetings within ESM and JVR, and increased co-operation between European societies of microcirculation related subjects such as vascular biology, angiology, and cardiovascular research. Attached to this newsletter are two documents putting forward the case for and against inclusion of the ESM membership in the BMS membership fee. If you have any comments on these two arguments please email them to me, and the committee will make a further recommendation for a motion at the next AGM to decisively rule this option either in or out.

 

Job Vacancies

Details of post and predoctoral vacancies, and occasionally lectureships are announced on the BMS

web page (www.microcirculation.org.uk). A recent addition to this is a Postdoctoral Position in Microcirculation & Septic Shock at the University of Sheffield.

 

Subscriptions

Although problems with the Direct Debit system are being addressed, we would be grateful if you could check that your accounts are being debited. For those who continue to pay their subscriptions by cheque, these are now due.

 

Email addresses

You should have been contacted in the last six months and asked if you preferred to be contacted by email for some of the BMS mailings. If you are receiving this as a hard copy, then either we do not have an email address for you, or you have stated that you prefer to receive hard copy. We will continue to provide hard copy of society handbooks, and abstract booklets for the foreseeable future.

Please be reassured that email will not be the only form of communication, unless you so request it.

 

Other forthcoming microcirculation and related meetings

European Society for Vascular Surgery, Dublin 5 – 7 September 2003

British Hypertension Society Cambridge, UK, 13-21 September 2003

8th Annual Meeting of the European Council for Blood Pressure and Cardiovascular Research, Seeheim Germany, 8 -10 October 2003

AACR sponsored meeting on Angiogenesis, Chicago, USA, October 15 -19 2003

IV interdisciplinary Euroconference on Angiogenesis, Co. Dublin, Ireland, 24 – 27 October 2003

An Introduction to Vascular Biology V, London UK, 24-26 November 2003

41st Spring Meeting of the BMS, University of Sheffield, April 5–6 2004

23rd European Conference on Microcirculation. Lisbon, Portugal. September 9 –10 2004

See www.microcirculation.org.uk for further details

 

Members News

Dr David Bates of the University of Bristol has been awarded the Microcirculatory Society Christian Crone Outstanding Young Investigator Award for 2003.

 

New Members

Dr Nick Brindle, Cardiovascular Department, Clinical Sciences Building, University of Leicester, PO Box 65, Leicester, LE2 7LX,

Tel: 01162525802, Fax: 01172523179, npjb1@le.ac.uk

Dr Zoe Brookes, Academic Anaesthesia Unit, K floor, Hallamshire Hospital, Sheffield, S10 2JF, Tel: 0114 271 2225, Fax: 0114 271 2771, zoe.brookes@sheffield.ac.uk

Dr Paul E Canning, Department of Ophthalmology and Vision Science, The Queen’s University of Belfast, Institute of Clinical Science, Royal Victoria Hospital, Belfast, BT12 6BA, Tel: 0289 026 35072,Fax: 0289 02632 699, p.canning@qub.ac.uk

Miss Claire E Clarkin, Department of Veterinary Basic Sciences, Royal Veterinary College, Royal College Street, London, NW1 0TU, Tel: 0207 468 5036, cclarkin@rvc.ac.uk

Ms Melissa J Cudmore, Department of Obstetrics and Gynaecology, Room S102, West Wing, Medical School, University of Birmingham, Birmingham, B15 2TT, Tel: 0121-414 3954, 0121-4142732, mjc221@bham.ac.uk

Dr Tim M Curtis, Department of Ophthalmology and Vision Science, The Queen’s University of Belfast, Institute of Clinical Science, Royal Victoria Hospital, Belfast, BT12 6BA, Tel: 02890 346 470, Fax: 02890 330 744, t.curtis@qub.ac.uk

Dr Tanyth E de Gooyer, Department of Ophthalmology and Vision Science, The Queen’s University of Belfast, Institute of Clinical Science, Royal Victoria Hospital, Belfast, BT12 6BA, Tel: 0289 026 35068, Fax: 0289 0263368, t.degooyer@qub.ac.uk

Miss Gillian Douglas, Maternal and Fetal Research Unit, 10th Floor, North Wing, St Thomas' Hospital, Lambeth Palace Road, London, SE1 7EH, Tel: 0207 928 9292 x 2247, Fax: 0207 620 1227, gillian.douglas@kcl.ac.uk

Mrs Sarah Duff, Department of Surgery, Christie Hospital NHS trust, Wilmslow Road, Manchester, Tel: 0161 446 3000, Fax: 0161 446 3365, sarah.duff@christie-tr.nwest.nhs.uk

Dr Alex Easton, University of Alberta, 261 Heritage Medical Research Centre, Edmonton, Alberta, Canada, T6G 252, 17824929250, 17804929249, easton@ualberta.ca

Miss Michelle Evans, Department of Veterinary Basic Sciences, Royal Veterinary College, Royal College Street, London, NW1 0TU, Tel: 0207 468 5036, mevans@rvc.ac.uk

Dr Paddy WF Hadoke, School of Molecular and Clinical Medicine, Endocrinology Unit, 2nd Floor OPD, Western General Hospital, Crewe Rd, Edinburgh, EH4 2XW, Tel: 0131 537 1742, Fax: 0131537 1012, phadoke@staffmail.ed.ac.uk

Dr Robin Hamilton, Faculty of Medicine, Floor E, Medical School, Queen's Medical Centre, Nottingham, NG7 2UH, Tel: 0115924 9924, Fax: 0115 970 9259, robin.hamilton@nottingham.ac.uk

Dr Davina J Honess, Tumour Microcirculation Group, Gray Cancer Institute, PO Box 100, Mount Vernon Hospital, Middlesex, HA6 2JR, Tel: 01923-828611, honess@gci.ac.uk

Miss Sarah J Hughes, Department of Ophthalmology and Vision Science, The Queen’s University of Belfast, Institute of Clinical Science, Royal Victoria Hospital, Belfast, BT12 6BA, Tel: 02890 346278, Fax: 02890 330744, s.j.hughes@qub.ac.uk

Dr Graham Lee, Department of Ophthalmology and Vision Science, The Queen’s University of Belfast, Institute of Clinical Science, Royal Victoria Hospital, Belfast, BT12 6BA, Tel: 0289 0240 503, Fax: 0289 0263 368, g.lee@qub.ac.uk

Valerie Leonhardt, School of Physics, Biomedical Research Group, University of Exeter, Exeter, EX4 4QL, Tel: 01392 264 092, Fax: 01392 264 111, V.leonhardt@ex.ac.uk

Mr Zhi-yong Li, Medical Engineering Division, Dept of Engineering, Queen Mary & Westfield College, Mile End Road, London, E1 4NS,Tel: 02078827899, Fax: 02089831007, Z.Y.Li@qmul.ac.uk

Mr Yiling Lu, Medical Engineering Division, Department of Engineering, Queen Mary & Westfield College, Mile End Road, London, E1 4NS, Tel: 02078827899, Fax: 0208983 1007, y.lu@qmul.ac.uk

Dr Denise McDonald, Department of Ophthalmology and Vision Science, The Queen’s University of Belfast, Institute of Clinical Science, Grovesnor Rd, Belfast, BT12 6BA, Tel: 0289 0330 744, Fax: 0289 0346 278, d.mcdonald@qub.ac.uk

Miss Andrea Reneifo, The University of Nottingham, Faculty of Medicine, Medical School, Queen's Medical Centre, Nottingham, NG7 2UH, Tel: 01159249924, Fax: 01159709259, mbxar@notts.ac.uk

Dr Mosharraf Sarker, Chemical and Life Section, School of Applied Sciences, University of Teeside, Middlesborough, TS1 3BA, Tel: 01642342 553, Fax: 01642 342 2401, m.sarker@tees.ac.uk

Professor Stephen K. Smith, Reproductive Molecular Research Group, Department of Obstetrics & Gynaecology, The Rosie Hospital, University of Cambridge, CB2 2SW, sks1000@cam.ac.uk

Professor Alan W. Stitt, Department of Ophthalmology and Vision Science, The Queen’s University of Belfast, Institute of Clinical Science, Royal Victoria Hospital, Belfast, BT12 6BA, Tel: 0289 026 3391, Fax: 0289 0263368, a.stitt@qub.ac.uk

Dr Karen Stuart-Smith, Dept of Anaesthesia, Borderley Green East, Birmingham, B9 5SS, Tel: 0121 424 3438, Fax: 0121 424 1441, stuartk@whsmithnet.co.uk.

Dr Nazahiya Sulaiman, The University of Nottingham, Faculty of Medicine, Floor E, Medical School, Queen's Medical Centre, Nottingham, NG7 2UH, Tel: 0115 924 9924, Fax: 0115 970 9259, mbxns@nottingham.ac.uk

Mr Richard Twycross-Lewis, Medical Engineering Division, Department of Engineering, Queen Mary & Westfield College, Mile End Road, London, E1 4NS, Tel: 020 7882 7877, Fax: 020 89831007, benchking1@yahoo.co.uk

Mr Ian Wilson, Tumour Microcirculation Group, Gray Cancer Institute, PO Box 100, Mount Vernon Hospital, Northwood, Middlesex, HA6 2JR, Tel: 01923828611, Fax: 01923835210, i.wilson@gci.ac.uk

 

Resignations

Dr R A Brown, Dr C S Collis, Sarah Rolleston.

 

 

Finally, may I wish you all a highly enjoyable and successful second half of the year, and hope that I will see you in Sheffield in April.

 

Yours sincerely,

Dave Bates

 

 

 

On the issue of compulsory membership of the European Society for Microcirculation

 

It is important that the arguments con get an equal airing to the arguments pro, especially as the AGM tends to be dominated by ESM members, whereas the BMS as a whole is not. The following arguments can be made against sine qua non membership of the European Society for Microcirculation (ESM) for BMS members.

 

1. Proposal 2a bars membership of the BMS to those who do not wish to join the ESM. It is surely a fundamental scientific liberty to be allowed to belong to one society (BMS) without being compelled to join a second, very different Society. A scientist is entitled to decide for himself/herself which scientific society(s) he/she belongs to. The proposal introduces coercion and removes freedom of choice.

 

2. Compulsory membership of the ESM will raise the BMS membership fee by a substantial % ; estimates seem to be of the order 75%-100%. This may well cause a decline in membership, either because some current members will discontinue their membership and/or in the longer term because the high fee deters new members.

 

3. It is debatable whether the substantial increase in membership fee represents value-for-money for many or most members of the BMS, although it should be a saving for those who are already ESM members. Only a fraction of the BMS membership (total about 200 at present) attend the biennial, i.e. once every 2 years, ESM

meetings. The reduced registration fee for ESM meetings will therefore be of no benefit to most BMS members, who will in effect subsidise the minority that attend ESM meetings. The other advantage of ESM membership is free on-line (but not hard copy) access to J. Vasc. Res. Summaries of all J. Vasc. Res. articles, however, are already available free on PubMed; online access lacks the convenience & portability

of physical copy; and not all (or even most?) BMS members are regular readers of J. Vasc. Res.

 

4. The ESM itself triggered the present proposal of compulsory ESM membership at national level, because it feels that it is failing to attract sufficient members and income in its own right. It can and should be argued that a society that cannot succeed in its own right does not merit the artificial support and big increase in income that it is seeking through the compulsory membership of those who would not otherwise join it. Coercion into membership of a society may be unacceptable to some BMS members, and ratification of clause 2a will preclude such individuals from retaining BMA membership. This seems an undesirable outcome, unlikely to benefit the Society.

 

Membership of ESM as a part of BMS membership

 

The ESM has, or should have, an important role to play by hosting the biennial European meetings in our field. Despite the increasing and vital contributions of more general aspects of molecular and cellular vascular biology to microcirculation research, the national societies in Europe testify to the continuing distinct identity of our field, and yet (since each society is quite small) also to the need for a regular forum where all European clinical and basic microvascular researchers can meet, be updated and informed, and interact with the

opportunity to set up new collaborations.

 

The ESM was set up essentially to do exactly this, i.e. to provide a biennial European meeting on behalf of the national societies. Because membership of the ESM is at present not an automatic part of national society membership, the ESM has a weak financial base, and its meetings therefore rely each time on the local organisers raising what is needed from whatever sources they can; a process that is becoming increasingly difficult and time consuming. In an effort to move forward, so that the ESM can become more self-sufficient and professional in running its meetings, and can offer other benefits to members of the national societies, the ESM executive committee has asked national societies to consider moving to a scheme in which part of an individual’s national society subscription is automatically gifted to the ESM, providing individual ESM membership for all European society members and putting the ESM’s finances on a sounder footing.

 

I believe that the ESM’s proposal makes good sense. It should lead to better European microcirculation conferences, something I hope we all support. Without an arrangement of this type, the ESM is in danger of not surviving for long. The BMS has been a consistent supporter of the ESM since its inception, regularly hosting its conferences and providing substantial financial backing. I doubt that the overall cost to the BMS of this proposal will be much higher than the one-off contributions we currently make to each ESM conference by sponsoring symposia, and I am certain that it has the potential to enable the ESM to become a more viable and influential entity.

 

To those who feel that they must have an individual right to choose whether they wish to be a part of the ESM as well as the BMS, I would make three points. First, that the ESM only exists as a vehicle to bring added value to national society membership. Second, that any individual who wishes to opt out of ESM membership will be allowed to do so, and the BMS will refund that part of their subscription. (They should bear in mind that registration as a non-member for the ESM meetings is likely to cost them more than this.) Third, that the BMS will not enter into this arrangement with ESM unless the other major national societies also do so, and will review the arrangement at each AGM with a view to withdrawing if the membership decides the benefits are not worth the costs.